Thank you for taking the time to read this information.
We are inviting you to take part in a study to help us understand if, how, and why, ethnicity affects the immune response to COVID-19 infection and vaccination in those working in healthcare settings. This research is part of a larger project called “UK-REACH: United Kingdom Research Study into Ethnicity and COVID-19 outcomes in Healthcare workers”. This study will also investigate the effectiveness of the seasonal influenza vaccination and will build on work from the BELIEVE study which ran during the 2020/21 flu season.
Before you decide whether to take part, it is important that you understand why the research is being done and what it will involve. Please read the following information carefully and discuss it with others if you wish. If you have questions, please contact us at firstname.lastname@example.org or on 07425 611865.
Previous research has found that healthcare workers and those from ethnic minority groups are at high risk of COVID-19 infection and may be at higher risk of severe disease than their white colleagues. We know that immune responses are key to the outcome of COVID-19 infection and vaccination.
BE-DIRECT aims to determine whether there are differences in immune responses to COVID-19 infection and vaccination (including booster vaccination) between ethnic groups in order to understand whether these differences may contribute to the observed differences in infection risk and COVID-19 outcome in different ethnic groups.
It is important that the seasonal influenza vaccine offers effective protection against infection throughout the influenza season which is usually between December to May in Leicester. Data is limited but evidence suggests that the effectiveness of the vaccine may be lower in people that have received previous influenza vaccinations. We will also investigate the effects of giving the flu jab together with the COVID-19 booster.
We will achieve this aim by combining information you provide us with on a questionnaire with information from your health record and by collecting blood samples. The blood samples will be analysed:
We are invited you to take part in this study as you:
We welcome people from all communities to join the study. Minority ethnic and migrant communities have had higher rates of COVID-19 hospital admissions, and we encourage people from these communities to consider taking part.
You do not need to have had COVID-19 infection or vaccination to join the study– it is important for us to include people who have and have not been infected or vaccinated.
You do not need to look after patients directly to join the study.
You can still take part even if you have already had your COVID-19 booster
We will ask you to:
You do not have to take part – it is up to you to decide whether or not you would like to take part. If you do decide to take part you are still free to withdraw at any time without giving a reason.
If you decide to take part, you will be asked to complete a consent form once you have had the opportunity to read this leaflet and ask any questions you might have. You will be able to download an electronic copy of your consent form to keep for your own information.
If you were originally part of the BELIEVE study and choose not to take part in BE-DIRECT your participation in BELIEVE will be complete as there are no further BELIEVE appointments.
If you were originally part of the DIRECT study and choose not to take part in BE-DIRECT you will have an appointment as planned for the DIRECT study in 6-9 months after your most recent COVID-19 vaccination or 6-9 months after enrolment if you have not received the COVID-19 vaccination.
Completing the initial questionnaire will take about 10 - 15 minutes. The collection of blood samples may cause mild discomfort and could leave a small bruise.
We may make available anonymous information from the study, labelled only with unique codes to researchers approved by the UK-REACH Study Steering Committee in discussion with the Chief Investigator and UK-REACH Core Management Group. This information will not identify you.
Although information including name and contact details will be kept on record, these data will only be used for two specific purposes:
People who do not need to know who you are will not be able to see the data collected during the registration process (including name and contact details). Your data will have a code number instead and stored separately from the questionnaire data.
We will ask for your permission to periodically link your questionnaire responses to data from your medical records (including data on COVID-19), from COVID-19 research study symptom trackers and apps (if you use these) and from other research studies you may be participating in. Linkage to your health records is important as it will allow us to understand the long-term effects of the pandemic on your health as well as any pre-existing conditions that might impact upon your immune system.
Linkage to your healthcare record is highly secure and can be summarised as follows:
Linkage to COVID-19 related outcomes (absences, swab test results, antibody results) in your occupational health record will be performed by a member of the occupational health department at UHL (not by researchers), and is strictly limited to information about COVID-19 and Influenza.
This process means that when researchers are analysing the data to answer research questions, they will not be able to identify you and that healthcare records with your personal details attached never leave the NHS.
We will not share any information about your health, or any other information you have given us, with your employer or professional body.
Once we have finished the study, we will keep some of the data so we can check the results. We will use the information you provide in reports and publications, for example, in scientific journals. This will be anonymised, meaning that we will write our reports in a way that no-one can work out that you took part in the study.
Access to any identifiable data (e.g. name, address) will be limited to select members of the research team and authorised individuals from the NHS or from the Sponsor (University of Leicester) or regulatory authorities. We expect to store the data for a period of 25 years, although this period will be reviewed by an expert Scientific Committee.
Information from the study, labelled with only a unique identifier (and therefore not identifiable as coming from you), will be made available to other approved researchers. This could include researchers in other countries and in commercial companies.
You can stop being part of the study at any time, without giving a reason. If you wish to withdraw from the study we would like you to optionally complete a withdrawal form. This is so we are clear whether or not we can continue to access your electronic healthcare records. If you do not wish to complete a withdrawal form, you can contact the study team by telephone or email (using the details provided below). We would like to continue to access your health records for up to 25 years, however, if you do not want this to happen then you can tell us on the withdrawal form or by contacting the study team by email or telephone (using the details provided below). If you do decide to withdraw then any information already collected will remain and be used in the study. No further data collection will be performed and we will not contact you again about this study.
We need to manage your records in specific ways for the research to be reliable. This means that we won’t be able to let you see or change the data we hold about you.
You can find out more about how we use your information:
Storage and future use of samples
Information relevant to you or your family might be discovered by the study of DNA. These measures are useful for research, but they are not the same as clinical genetic tests. Research genetic measures are not of a high enough standard for diagnosis. Therefore, we will not routinely provide you with the results of all the genetic variants measured in the study. In rare situations we may advise a participant to seek medical advice based on a research result for a specific genetic variant for which there may be medical treatment. For example, one which causes very high blood cholesterol which might be lowered by medication. A Scientific Committee based on expert advice will decide what is considered to be a genetic variant that can be medically treated. On the consent form, we will ask you to choose whether you would wish to be contacted if we do find such a variation. The Clinical Genetics Department at the Leicester Royal Infirmary have a dedicated genetic counselling clinic for patients where genetic variations have been identified in a research study. This will offer advice to patients on the significance of what has been discovered and the steps the patient can take to reduce the likelihood of this having an impact on health in the future.
However, it is important that you understand that we cannot identify all genetic variants for which there may be a medical treatment and our ability to continue the study and to contact participants will be subject to further funding. As a research study we do not have the resources that a screening programme has, and the research genetic measures are not of a comparable standard to genetic testing that is a part of a screening programme. It is important you understand that this study is not a substitute for medical screening, clinical advice or clinical care.
It is unlikely that you will be harmed by taking part in this study. If you wish to complain about any aspect of the way in which you have been approached or treated during the course of this study, please contact UK-REACH project manager Claire Garwood (email@example.com; 07425 611865) who will acknowledge receipt of the complaint, investigate, and report back to you within a reasonable period of time.
If something does go wrong and you are harmed during the research and this is due to someone’s negligence then you may have grounds for legal action for compensation against the University of Leicester but you may have to pay your legal costs. The normal NHS complaints service will still be available to you (if appropriate).
We will publish findings from the research in scientific journals. We will summarise published research on a study website: www.uk-reach.org.
Information that you provide in the questionnaires, including quotes, may be used in publications although they will be anonymous.
This research is led by Dr Manish Pareek at the University of Leicester. The study has been supported by funding from UK Research and Innovation.
This study has been reviewed and approved by an independent group of people called a Research Ethics Committee (Brighton and Sussex) and by the University of Leicester as Sponsor. All research that involves NHS patients or staff, information from NHS medical records or uses NHS premises or facilities must be approved by an NHS Research Ethics Committee before it goes ahead. Approval does not guarantee that you will not come to any harm if you take part. However, approval means that the committee is satisfied that your rights will be respected, that any risks have been reduced to a minimum and balanced against possible benefits and that you have been given sufficient information on which to make an informed decision
Thank you for reading this information sheet.
Tel: 07425 611865